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The Lancet Oncology
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[Articles] Afatinib for patients with lung adenocarcinoma and epidermal growth factor receptor mutations (LUX-Lung 2): a phase 2 trial
01-May-2012
Afatinib shows activity in the treatment of patients with advanced lung adenocarcinoma with EGFR...
[Articles] Afatinib versus placebo for patients with advanced, metastatic non-small-cell lung cancer after failure of erlotinib, gefitinib, or both, and one or two lines of chemotherapy (LUX-Lung 1): a phase 2b/3 randomised trial
01-May-2012
Although we recorded no benefit in terms of overall survival with afatinib (which might have been...
[Articles] Anal human papillomavirus infection and associated neoplastic lesions in men who have sex with men: a systematic review and meta-analysis
01-May-2012
Anal HPV and anal cancer precursors were very common in MSM. However, on the basis of restricted...
[Articles] Celecoxib plus hormone therapy versus hormone therapy alone for hormone-sensitive prostate cancer: first results from the STAMPEDE multiarm, multistage, randomised controlled trial
01-May-2012
Celecoxib 400 mg twice daily for up to 1 year is insufficiently active in patients starting hormone...
[Articles] Combined immunotherapy with granulocyte-macrophage colony-stimulating factor-transduced allogeneic prostate cancer cells and ipilimumab in patients with metastatic castration-resistant prostate cancer: a phase 1 dose-escalation trial
01-May-2012
GVAX combined with 3ยท0 mg/kg ipilimumab is tolerable and safe for patients with mCRPC. Further...
[Articles] Conjugated equine oestrogen and breast cancer incidence and mortality in postmenopausal women with hysterectomy: extended follow-up of the Women's Health Initiative randomised placebo-controlled trial
01-May-2012
Our findings provide reassurance for women with hysterectomy seeking relief of climacteric symptoms...
[Articles] Effects of regular aspirin on long-term cancer incidence and metastasis: a systematic comparison of evidence from observational studies versus randomised trials
01-May-2012
Observational studies show that regular use of aspirin reduces the long-term risk of several...
[Articles] Gefitinib versus placebo as maintenance therapy in patients with locally advanced or metastatic non-small-cell lung cancer (INFORM; C-TONG 0804): a multicentre, double-blind randomised phase 3 trial
01-May-2012
Maintenance treatment with gefitinib significantly prolonged progression-free survival compared...
[Articles] Ipilimumab and a poxviral vaccine targeting prostate-specific antigen in metastatic castration-resistant prostate cancer: a phase 1 dose-escalation trial
01-May-2012
The use of a vaccine targeting PSA that also enhances co-stimulation of the immune system did not...
[Articles] Ipilimumab in patients with melanoma and brain metastases: an open-label, phase 2 trial
01-May-2012
Ipilimumab has activity in some patients with advanced melanoma and brain metastases, particularly...
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